Pseudoautologous blood stem cell transplantation for refractory chronic graft-versus-host disease

I. Pusic, S. Z. Pavletic, A. Kessinger, S. R. Tarantolo, M. R. Bishop

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

A female patient with AML received an allogeneic BMT from her brother. She experienced two relapses managed with chemotherapy and donor leukocyte infusions. The patient subsequently developed extensive therapy-refractory chronic GVHD. Pseudoautologous blood stem cell transplantation was performed as a salvage treatment for chronic GVHD. Her blood stem cells were easily mobilized with cyclophosphamide and G-CSF. The conditioning regimen was well tolerated and consisted of 200 mg/kg cyclophosphamide and horse-derived antithymocyte globulin. A total of 4.03 × 106/kg CD34+ cells were infused and hematological recovery was rapid. Chronic GVHD improved with the ability to taper steroids. Nine months post transplantation the patient died from leukemia.

Original languageEnglish (US)
Pages (from-to)709-710
Number of pages2
JournalBone marrow transplantation
Volume29
Issue number8
DOIs
StatePublished - 2002

Keywords

  • AML
  • Chronic graft-versus-host disease
  • Hematopoietic stem cell transplantation

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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