Psychosocial factors and the course of cervical intra-epithelial neoplasia: A prospective study

E. S.M. Tiersma, M. L. Van Der Lee, B. Garssen, A. A.W. Peters, A. P. Visser, G. J. Fleuren, K. M. Van Leeuwen, S. Le Cessie, K. Goodkin

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Objective. To investigate the influence of psychosocial factors on the course of cervical intra-epithelial neoplasia (CIN). Methods. A group of 93 patients with CIN 1 or 2 was followed for 2.25 years by half-yearly colposcopy and cytology. Negatively-rated life events, social support, and coping style were studied in relation to distress during follow-up and in relation to time till progression and regression of CIN. Human papillomavirus (HPV) infection was controlled for as well as sick role bias caused by suspicion of having cervical cancer and distress due to the abnormal cervical smear. Results. During follow-up, progression was found in 20 patients (22%), stable disease in 22 patients (24%), and regression in 51 patients (55%). Negatively-rated life events and lack of social support predicted distress longitudinally. No association was found between progression or regression of CIN and negatively-rated life events, lack of social support, coping style, and distress. Conclusion. We found no evidence that psychosocial factors influence the course of CIN.

Original languageEnglish (US)
Pages (from-to)879-886
Number of pages8
JournalGynecologic Oncology
Issue number3
StatePublished - Jun 2005
Externally publishedYes


  • Adaptation psychological
  • Cervical intra-epithelial neoplasia
  • Follow-up studies
  • Health behavior
  • Life change events
  • Psychology
  • Psychoneuroimmunology
  • Social support

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology


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