PTTG1: a Unique Regulator of Stem/Cancer Stem Cells in the Ovary and Ovarian Cancer

Seema Parte, Irma Virant-Klun, Manish Patankar, Surinder K. Batra, Alex Straughn, Sham S. Kakar

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Origin of cancer stem cells (CSCs) and mechanisms by which oncogene PTTG1 contributes to tumor progression via CSCs is not known. Ovarian CSCs exhibit characteristics of self-renewal, tumor-initiation, growth, differentiation, drug resistance, and tumor relapse. A common location of putative origin, namely the ovarian surface epithelium, is shared between the normal stem and CSC compartments. Existence of ovarian stem cells and their co-expression with CSC signatures suggests a strong correlation between origin of epithelial cancer and CSCs. We hereby explored a putative oncogene PTTG1 (Securin), reported to be overexpressed in various tumors, including ovarian. We report a previously overlooked role of PTTG1 as a marker of CSCs thereby modulating CSC, germline, and stemness-related genes. We further characterized PTTG1’s ability to regulate (cancer) stem cell-associated self-renewal and epithelial-mesenchymal transition pathways. Collectively, the data sheds light on a potential target expressed during ovarian tumorigenesis and metastatically disseminated ascites CSCs in the peritoneal cavity. Present study highlights this unconventional, under-explored role of PTTG1 in regulation of stem and CSC compartments in ovary, ovarian cancer and ascites and highlights it as a potential candidate for developing CSC specific targeted therapeutics.

Original languageEnglish (US)
Pages (from-to)866-879
Number of pages14
JournalStem Cell Reviews and Reports
Volume15
Issue number6
DOIs
StatePublished - Dec 1 2019

Keywords

  • Cancer stem cells
  • Oncogene
  • Ovarian cancer
  • Ovary
  • PTTG1
  • Securin
  • Stem cells

ASJC Scopus subject areas

  • Cell Biology
  • Cancer Research

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