Puberty in cystic fibrosis

Bracha Goldsweig, Beth Kaminski, Aniket Sidhaye, Scott M. Blackman, Andrea Kelly

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


Historically, delayed puberty was considered a common clinical feature of cystic fibrosis (CF). More recent reports have documented normal pubertal progression in the majority of individuals with CF. However, youth with more severe disease are still at risk for delayed puberty. Careful evaluation of pubertal development in children and adolescents with CF is important as pubertal timing impacts linear growth, bone mineral accrual, body image and psychosocial wellbeing, all of which can also be impacted directly by CF. This article reviews the physiology of puberty, timing of puberty in CF, evaluation of pubertal development, and the differential diagnosis, evaluation, and management of delayed and precocious puberty in people with CF.

Original languageEnglish (US)
Pages (from-to)S88-S94
JournalJournal of Cystic Fibrosis
StatePublished - Oct 2019
Externally publishedYes


  • Cystic fibrosis
  • Delayed puberty
  • Growth
  • Puberty

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine


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