Pulmonary arteriovenous malformations: Cerebral ischemia and neurologic manifestations

M. Moussouttas, P. Fayad, M. Rosenblatt, M. Hashimoto, J. Pollak, K. Henderson, T. Y.Z. Ma, R. I. White

Research output: Contribution to journalArticle

201 Scopus citations


Background: There is an increasingly recognized association between pulmonary arteriovenous malformations (PAVM) and cerebral ischemia, frequently attributed to paradoxical embolization. PAVM occur in 20 to 30% of the hereditary hemorrhagic telangiectasia (HHT) population. Objective: To evaluate the risk determinants for cerebral ischemia and neurologic manifestations in patients with PAVM. Methods: A retrospective cross-sectional study was performed on consecutive patients admitted between 1988 and 1992 for treatment of PAVM. The number of PAVM, feeding artery (FA) diameters, and aneurysmal sizes were determined by pulmonary angiography. Patients were categorized as having single or multiple PAVM with an FA diameter of ≥3 mm. History, examination, and cerebral imaging studies were used to determine the prevalence of neurologic manifestations. Patients were defined as having cerebral paradoxical embolization if there was radiologic evidence of cortical infarction. Results: There were 75 cases: 26 single PAVM and 49 multiple PAVM. Cortical infarction was present in 14% of patients with single PAVM. Patients with multiple PAVM had a greater prevalence of any infarction (OR 3.2; 95% CI, 1.2 to 9.44, p = 0.030), cortical infarctions (OR 2.3; 95% CI, 0.58 to 9.2, p = 0.230), subcortical infarctions (OR 2.1; 95% CI, 0.58 to 7.95, p = 0.249), abscesses (OR 2.3; 95% CI, 0.46 to 11.94; p = 0.295), and seizures (OR 6.4, 95% CI 0.77 to 53.2, p = 0.054). Patients with multiple PAVM had markedly greater odds of having any clinical or radiologic evidence of cerebral ischemic involvement (OR 4.5; 95% CI, 1.47 to 14; p = 0.008). Conclusion: There is a strong association between single PAVM and various neurologic manifestations. The prevalence is greater for patients with multiple PAVM, suggesting increased predisposition for paradoxical embolization with a greater number of malformations.

Original languageEnglish (US)
Pages (from-to)959-964
Number of pages6
Issue number7
StatePublished - Oct 10 2000

ASJC Scopus subject areas

  • Clinical Neurology

Fingerprint Dive into the research topics of 'Pulmonary arteriovenous malformations: Cerebral ischemia and neurologic manifestations'. Together they form a unique fingerprint.

  • Cite this

    Moussouttas, M., Fayad, P., Rosenblatt, M., Hashimoto, M., Pollak, J., Henderson, K., Ma, T. Y. Z., & White, R. I. (2000). Pulmonary arteriovenous malformations: Cerebral ischemia and neurologic manifestations. Neurology, 55(7), 959-964. https://doi.org/10.1212/WNL.55.7.959