Pulmonary function reductions among potentially susceptible subgroups of agricultural workers in Colorado and Nebraska

Stephen J. Reynolds, Maggie L. Clark, Niels Koehncke, Susanna Von Essen, Linda Prinz, Thomas J. Keefe, John Mehaffy, Mary Bradford, Brian Cranmer, Margaret E. Davidson, Ivana V. Yang, James B. Burch

Research output: Contribution to journalReview article

12 Scopus citations

Abstract

OBJECTIVE: Organic dust inhalation has been associated with adverse respiratory responses among agricultural workers. We evaluated factors that may confer increased susceptibility to these health effects. METHODS: We quantified personal work shift exposures to inhalable dust, endotoxin, and its 3-hydroxy fatty acid constituents, and evaluated changes in pulmonary function among 137 grain elevator, cattle feedlot, dairy, and corn farm workers. RESULTS: Increased dust exposure was associated with work shift reductions in lung function. Although interpretation is limited because of small samples, a suggestion of stronger exposure-response relationships was observed among smokers, as well as workers reporting pesticide/herbicide application, asthma, or allergies, and those with genetic polymorphisms (TLR4) (Pinteraction ≤ 0.05). CONCLUSIONS: A better understanding of factors leading to increased susceptibility of adverse respiratory outcomes is needed to optimize exposure reduction strategies and develop more comprehensive wellness programs.

Original languageEnglish (US)
Pages (from-to)632-641
Number of pages10
JournalJournal of occupational and environmental medicine
Volume54
Issue number5
DOIs
StatePublished - May 2012

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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    Reynolds, S. J., Clark, M. L., Koehncke, N., Von Essen, S., Prinz, L., Keefe, T. J., Mehaffy, J., Bradford, M., Cranmer, B., Davidson, M. E., Yang, I. V., & Burch, J. B. (2012). Pulmonary function reductions among potentially susceptible subgroups of agricultural workers in Colorado and Nebraska. Journal of occupational and environmental medicine, 54(5), 632-641. https://doi.org/10.1097/JOM.0b013e31824d2e1c