Pulmonary langerhans cell histiocytosis: PET/CT for initial workup and treatment response evaluation

Neil J. Hansen, Jordan H. Hankins

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

A 40-year-old man underwent pan-endoscopy owing to abdominal pain. Biopsies of the gastrointestinal tract demonstrated diffuse Langerhans cell histiocytosis. PET/CT was done, with CT demonstrating classic pulmonary manifestations of Langerhans cell histiocytosis that had association with intense FDG uptake on PET. Bowel appeared normal. Treatment was initiated with smoking cessation and 6 cycles of cytarabine. Follow-up PET/CT after initial treatment demonstrated improvement of parenchymal abnormalities seen on CT, with resolution of hypermetabolic activity. Maintenance chemotherapy was initiated. PET/CT is increasingly being used for initial staging and treatment response assessment in this rare disorder.

Original languageEnglish (US)
Pages (from-to)153-155
Number of pages3
JournalClinical nuclear medicine
Volume40
Issue number2
DOIs
StatePublished - Feb 21 2015

Keywords

  • LCH
  • Langerhans cell histiocytosis
  • PET/CT
  • disease response

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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