Pulmonary necrobiotic nodules in crohn’s disease: A rare extra-intestinal manifestation

Karim El-Kersh, Mostafa Fraig, Rodrigo Cavallazzi, Mohamed Saad, Rafael L. Perez

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Pulmonary necrobiotic nodules represent a rare extra-intestinal manifestation of Crohn’s disease. Histologically, they are composed of sterile aggregates of inflammatory cells with necrosis. The differential diagnosis is broad, and exclusion of infectious etiologies is mandatory before starting immunosuppressive therapy. Here, we present the fifth reported case of pulmonary necrobiotic nodules in Crohn’s disease. Our patient had new-onset Crohn’s disease associated with both cavitating and non-cavitating lung nodules that were confirmed to be necrobiotic nodules by biopsy. The patient was started on mesalamine and prednisone, with subsequent improvement of his gastrointestinal symptoms and regression of the necrobiotic nodules.

Original languageEnglish (US)
Pages (from-to)e190-e192
JournalRespiratory care
Issue number12
StatePublished - Dec 2014
Externally publishedYes


  • Crohn’s disease
  • Pulmonary necrobiotic nodules
  • Video-assisted thoracoscopy

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine


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