Abstract
Extramedullary hematopoiesis (EMH) is a phenomenon in which benign immature hematopoietic cells are found in sites other than the bone marrow. Although usually associated with an underlying hematologic abnormality such as myelofibrosis, it can be found in some physiologic states or occasionally within solid tumors. In most instances, foci of EMH contain elements of all cell lineages. Presented here is the second reported case of EMH occurring in a low-grade clear cell renal cell carcinoma in a patient without evidence of hematologic disease. As previously, it manifested as pure erythropoiesis as confirmed by morphology and immunohistochemistry. It is possible that this finding is related to erythropoietin secretion by the tumor and not hematologic malignancy.
Original language | English (US) |
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Pages (from-to) | 544-546 |
Number of pages | 3 |
Journal | International Journal of Surgical Pathology |
Volume | 18 |
Issue number | 6 |
DOIs | |
State | Published - Dec 2010 |
Keywords
- erythropoiesis
- erythropoietin
- extramedullary hematopoiesis
- glycophorin C
- renal cell carcinoma
ASJC Scopus subject areas
- Anatomy
- Surgery
- Pathology and Forensic Medicine