Putting electrospun nanofibers to work for biomedical research

Jingwei Xie, Xiaoran Li, Younan Xia

Research output: Contribution to journalArticle

264 Scopus citations

Abstract

Electrospinning has been exploited for almost one century to process polymers and related materials into nanofibers with controllable compositions, diameters, porosities, and porous structures for a variety of applications. Owing to its high porosity and large surface area, a non-woven mat of electrospun nanofibers can serve as an ideal scaffold to mimic the extracellular matrix for cell attachment and nutrient transportation. The nanofiber itself can also be functionalized through encapsulation or attachment of bioactive species such as extracellular matrix proteins, enzymes, and growth factors. In addition, the nanofibers can be further assembled into a variety of arrays or architectures by manipulating their alignment, stacking, or folding. All these attributes make electrospinning a powerful tool for generating nanostructured materials for a range of biomedical applications that include controlled release, drug delivery, and tissue engineering.

Original languageEnglish (US)
Pages (from-to)1775-1792
Number of pages18
JournalMacromolecular Rapid Communications
Volume29
Issue number22
DOIs
StatePublished - Nov 19 2008
Externally publishedYes

Keywords

  • Biological applications of polymers
  • Biomaterials
  • Electrospinning
  • Fibers

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

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