Pyocyanin from Pseudomonas aeruginosa inhibits prostacyclin release from endothelial cells

J. M. Kamath, B. E. Britigan, C. D. Cox, D. M. Shasby

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Pseudomonas aeruginosa pneumonia causes a vasculitis of small pulmonary arteries. While the fully developed lesion demonstrates vessel wall necrosis, the early lesion is remarkable for preservation of viable endothelium despite vessel wall invasion by bacteria. Pyocyanin, an exoproduct of P. aeruginosa, markedly inhibited prostacyclin production by pulmonary artery endothelial cells without causing cell lysis. Pyocyanin might alter vascular homeostasis in the absence of cytolysis.

Original languageEnglish (US)
Pages (from-to)4921-4923
Number of pages3
JournalInfection and immunity
Volume63
Issue number12
DOIs
StatePublished - 1995

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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