TY - JOUR
T1 - Pyoverdine, a siderophore from Pseudomonas aeruginosa, translocates into C. elegans, removes iron, and activates a distinct host response
AU - Kang, Donghoon
AU - Kirienkoa, Daniel R.
AU - Webster, Phillip
AU - Fisher, Alfred L.
AU - Kirienko, Natalia V.
N1 - Publisher Copyright:
© 2018 The Author(s).
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Pseudomonas aeruginosa, a re-emerging, opportunistic human pathogen, encodes a variety of virulence determinants. Pyoverdine, a siderophore produced by this bacterium, is essential for pathogenesis in mammalian infections. This observation is generally attributed to its roles in acquiring iron and/or regulating other virulence factors. Here we report that pyoverdine translocates into the host, where it binds and extracts iron. Pyoverdine-mediated iron extraction damages host mitochondria, disrupting their function and triggering mitochondrial turnover via autophagy. The host detects this damage via a conserved mitochondrial surveillance pathway mediated by the ESRE network. Our findings illuminate the pathogenic mechanisms of pyoverdine and highlight the importance of this bacterial product in host-pathogen interactions.
AB - Pseudomonas aeruginosa, a re-emerging, opportunistic human pathogen, encodes a variety of virulence determinants. Pyoverdine, a siderophore produced by this bacterium, is essential for pathogenesis in mammalian infections. This observation is generally attributed to its roles in acquiring iron and/or regulating other virulence factors. Here we report that pyoverdine translocates into the host, where it binds and extracts iron. Pyoverdine-mediated iron extraction damages host mitochondria, disrupting their function and triggering mitochondrial turnover via autophagy. The host detects this damage via a conserved mitochondrial surveillance pathway mediated by the ESRE network. Our findings illuminate the pathogenic mechanisms of pyoverdine and highlight the importance of this bacterial product in host-pathogen interactions.
KW - Caenorhabditis elegans
KW - Host response
KW - Mitochondrial damage
KW - Pathogenesis
KW - Pseudomonas aeruginosa
KW - Pyoverdine
KW - Siderophore
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U2 - 10.1080/21505594.2018.1449508
DO - 10.1080/21505594.2018.1449508
M3 - Article
C2 - 29532717
AN - SCOPUS:85049070690
SN - 2150-5594
VL - 9
SP - 804
EP - 817
JO - Virulence
JF - Virulence
IS - 1
ER -