TY - JOUR
T1 - QRS analysis using wavelet transformation for the prediction of response to cardiac resynchronization therapy
T2 - A prospective pilot study
AU - Vassilikos, Vassilios P.
AU - Mantziari, Lilian
AU - Dakos, Georgios
AU - Kamperidis, Vasileios
AU - Chouvarda, Ioanna
AU - Chatzizisis, Yiannis S.
AU - Kalpidis, Panagiotis
AU - Theofilogiannakos, Efstratios
AU - Paraskevaidis, Stelios
AU - Karvounis, Haralambos
AU - Mochlas, Sotirios
AU - Maglaveras, Nikolaos
AU - Styliadis, Ioannis H.
N1 - Funding Information:
LM is supported by grants by the European Heart Rhythm Association and the Hellenic Cardiological Society .
PY - 2014/1
Y1 - 2014/1
N2 - Background Wider QRS and left bundle branch block morphology are related to response to cardiac resynchronization therapy (CRT). A novel time-frequency analysis of the QRS complex may provide additional information in predicting response to CRT. Methods Signal-averaged electrocardiograms were prospectively recorded, before CRT, in orthogonal leads and QRS decomposition in three frequency bands was performed using the Morlet wavelet transformation. Results Thirty eight patients (age 65 ± 10 years, 31 males) were studied. CRT responders (n = 28) had wider baseline QRS compared to non-responders and lower QRS energies in all frequency bands. The combination of QRS duration and mean energy in the high frequency band had the best predicting ability (AUC 0.833, 95%CI 0.705-0.962, p = 0.002) followed by the maximum energy in the high frequency band (AUC 0.811, 95%CI 0.663-0.960, p = 0.004). Conclusions Wavelet transformation of the QRS complex is useful in predicting response to CRT.
AB - Background Wider QRS and left bundle branch block morphology are related to response to cardiac resynchronization therapy (CRT). A novel time-frequency analysis of the QRS complex may provide additional information in predicting response to CRT. Methods Signal-averaged electrocardiograms were prospectively recorded, before CRT, in orthogonal leads and QRS decomposition in three frequency bands was performed using the Morlet wavelet transformation. Results Thirty eight patients (age 65 ± 10 years, 31 males) were studied. CRT responders (n = 28) had wider baseline QRS compared to non-responders and lower QRS energies in all frequency bands. The combination of QRS duration and mean energy in the high frequency band had the best predicting ability (AUC 0.833, 95%CI 0.705-0.962, p = 0.002) followed by the maximum energy in the high frequency band (AUC 0.811, 95%CI 0.663-0.960, p = 0.004). Conclusions Wavelet transformation of the QRS complex is useful in predicting response to CRT.
KW - Biventricular pacing
KW - Heart failure
KW - Morlet wavelet transform
KW - QRS complex
KW - Signal processing
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U2 - 10.1016/j.jelectrocard.2013.08.003
DO - 10.1016/j.jelectrocard.2013.08.003
M3 - Article
C2 - 24034302
AN - SCOPUS:84891481352
SN - 0022-0736
VL - 47
SP - 59
EP - 65
JO - Journal of Electrocardiology
JF - Journal of Electrocardiology
IS - 1
ER -