Qualitative and quantitative analyses of resin-bound organic compounds

Mark Irving, Jason Cournoyer, Rongshi Li, Chris Santos, Bing Yan

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Methods for qualitative and quantitative analyses of resin-bound organic compounds are essential tools for chemistry development in solid-phase combinatorial and parallel syntheses. Here we discuss the use of gel-phase 19F NMR, the fluoride ion-selective electrode method, and spectrophotometry for monitoring solid-phase reactions. Our results indicate that the application of these diverse methods for analyzing the outcome of solid-phase combinatorial synthesis are sensitive and conclusive.

Original languageEnglish (US)
Pages (from-to)353-362
Number of pages10
JournalCombinatorial Chemistry and High Throughput Screening
Volume4
Issue number4
DOIs
StatePublished - 2001

ASJC Scopus subject areas

  • Drug Discovery
  • Computer Science Applications
  • Organic Chemistry

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