Qualitative Profiling of the Humoral Immune Response Elicited by rVSV-ΔG-EBOV-GP Using a Systems Serology Assay, Domain Programmable Arrays

Mariano Sanchez-Lockhart, Daniel S. Reyes, Jeanette C. Gonzalez, Karla Y. Garcia, Erika C. Villa, Bradley P. Pfeffer, John C. Trefry, Jeffrey R. Kugelman, Margaret L. Pitt, Gustavo F. Palacios

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Sanchez-Lockhart et al. describe a systems serology platform (Domain Programmable Arrays) to identify epitopes targeted after vaccination or infection. They characterize the humoral response in rVSV-ΔG-EBOV-glycoprotein-vaccinated non-human primates, observing bias on the immunoglobulin isotype epitope recognition pattern, showing the value of the tool to qualitatively measure humoral responses.

Original languageEnglish (US)
Pages (from-to)1050-1059.e5
JournalCell Reports
Volume24
Issue number4
DOIs
StatePublished - Jul 24 2018

Keywords

  • Domain Programmable Arrays
  • EBOV
  • G-EBOV-GP
  • epitope mapping
  • humoral response
  • rVSV-Δ
  • system serology

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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