Controle de qualite des monodoses de 7 principes actifs

Translated title of the contribution: Quality control of 7 drugs unit doses

D. Feldman, O. Ghribi, J. Ouary, G. Dumortier, K. Degrassat, R. Leverge

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The stability of 7 drugs (alimemazine, amitriptyline, chlorpromazine, cyamemazine, heptaminol, periciazine and sodium valproate) in unit dose solution packaged in ambercoloured glass vial was studied using different concentrations, both at 4 °C and 30 °C, along 28 days. The solution was obtained from the dilution of commercially available oral solution. The determinations were carried out by high performance liquid chromatography using an UV spectrophotometric detection. The loss was always inferior to 5% for chlorpromazine and cyamemazine solutions. A loss superior to 10% was detected in the case of heptaminol, periciazine and sodium valproate.

Translated title of the contributionQuality control of 7 drugs unit doses
Original languageFrench
Pages (from-to)268-271
Number of pages4
JournalJournal de Pharmacie Clinique
Volume17
Issue number4
StatePublished - Dec 1998

Keywords

  • Aqueous solution
  • Dilution
  • Glass
  • Psychotric drugs
  • Stability
  • Unit dose

ASJC Scopus subject areas

  • Pharmacology (medical)

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