Quality of life in pancreatic cancer: Analysis by stage and treatment

Stefano Crippa, Ismael Domínguez, J. Ruben Rodríguez, Oswaldo Razo, Sarah P. Thayer, David P. Ryan, Andrew L. Warshaw, Carlos Fernández-Del Castillo

Research output: Contribution to journalArticlepeer-review

67 Scopus citations

Abstract

In pancreatic cancer patients, survival and palliation of symptoms should be balanced with social and functional impairment, and for this reason, health-related quality of life measurements could play an important role in the decision-making process. The aim of this work was to evaluate the quality of life and survival in 92 patients with different stages of pancreatic adenocarcinoma who underwent surgical and/or medical interventions. Patients were evaluated with the Functional Assessment of Cancer Therapy questionnaires at diagnosis and follow-up (3 and 6 months). At diagnosis, 28 patients (30.5%) had localized disease (group 1) and underwent surgical resection, 34 (37%) had locally advanced (group 2), and 30 (32.5%) metastatic disease (Group 3). Improvement in quality of life was found in group 1, while in group 3, it decreased at follow-up (p = 0.03). No changes in quality of life in group 2 were found. Chemotherapy/chemoradiation seems not to significantly modify quality of life in groups 2 and 3. Median survival time for the entire cohort was 9.8 months (range, 1-24). One-year survival was 74%, 30%, and 16% for groups 1, 2, and 3 respectively (p = 0.001). Pancreatic cancer prognosis is still dismal. In addition to long-term survival benefits, surgery impacts favorably quality of life.

Original languageEnglish (US)
Pages (from-to)783-794
Number of pages12
JournalJournal of Gastrointestinal Surgery
Volume12
Issue number5
DOIs
StatePublished - May 2008

Keywords

  • Meaningful important difference
  • Palliation
  • Pancreatic cancer
  • Quality of life
  • Survival

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology

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