Quantification of Cell Adhesion Strength using Energy Dissipation from Quartz Microbalance with Dissipation Monitoring

Amir Monemian Esfahani, Jordan Rosenbohm, Ruiguo Yang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We propose a mechanical model that describes the energy dissipation process in the probing of cell adhesion using quartz crystal microbalance with dissipation monitoring (QCM-D). The model considers the QCM-D disk as a harmonic oscillator and the friction between the disk and the cell is modeled as molecular bond rupturing and the fluidic slip at the interface. The bond formation and rupture events are governed by relative motion between the sensor disk and the cell membrane. We consider this interaction as the main energy dissipation channel for the oscillator, as the dynamic molecular bond rupture and the viscous damping of the trapped liquid at the cell/disk interfacial layer contribute to the most energy loss during the harmonic oscillation. The energy loss due to the frictional slip of the stress fiber/cytoplasm is insignificant compared with the bond rupture. At high bond number conditions, the energy dissipation will be dominated by the bond rupture events at the focal adhesion, and bond number and the size of focal adhesion are linearly related to the energy dissipation factors. These findings can serve as an analytical tool for QCM-D based cell adhesion assays.

Original languageEnglish (US)
Title of host publication19th IEEE International Conference on Nanotechnology, NANO 2019
PublisherIEEE Computer Society
Pages265-268
Number of pages4
ISBN (Electronic)9781728128917
DOIs
StatePublished - Jul 2019
Event19th IEEE International Conference on Nanotechnology, NANO 2019 - Macau, China
Duration: Jul 22 2019Jul 26 2019

Publication series

NameProceedings of the IEEE Conference on Nanotechnology
Volume2019-July
ISSN (Print)1944-9399
ISSN (Electronic)1944-9380

Conference

Conference19th IEEE International Conference on Nanotechnology, NANO 2019
CountryChina
CityMacau
Period7/22/197/26/19

ASJC Scopus subject areas

  • Bioengineering
  • Electrical and Electronic Engineering
  • Materials Chemistry
  • Condensed Matter Physics

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  • Cite this

    Esfahani, A. M., Rosenbohm, J., & Yang, R. (2019). Quantification of Cell Adhesion Strength using Energy Dissipation from Quartz Microbalance with Dissipation Monitoring. In 19th IEEE International Conference on Nanotechnology, NANO 2019 (pp. 265-268). [8993951] (Proceedings of the IEEE Conference on Nanotechnology; Vol. 2019-July). IEEE Computer Society. https://doi.org/10.1109/NANO46743.2019.8993951