TY - JOUR
T1 - Quantification of left ventricular torsion and diastolic recoil using cardiovascular magnetic resonance myocardial feature tracking
AU - Kowallick, Johannes T.
AU - Lamata, Pablo
AU - Hussain, Shazia T.
AU - Kutty, Shelby
AU - Steinmetz, Michael
AU - Sohns, Jan M.
AU - Fasshauer, Martin
AU - Staab, Wieland
AU - Unterberg-Buchwald, Christina
AU - Bigalke, Boris
AU - Lotz, Joachim
AU - Hasenfuß, Gerd
AU - Schuster, Andreas
N1 - Publisher Copyright:
© 2014 Kowallick et al.
PY - 2014/10/6
Y1 - 2014/10/6
N2 - Methods: Short-axis cine stacks were acquired at rest and during dobutamine stimulation (10 and 20 μg•kg-1•min-1) in 10 healthy volunteers. Rotational displacement was analysed for all slices. A complete 3D-LV rotational model was developed using linear interpolation between adjacent slices. Torsion was defined as the difference between apical and basal rotation, divided by slice distance. Depending on the distance between the most apical (defined as 0% LV distance) and basal (defined as 100% LV distance) slices, four different models for the calculation of torsion were examined: Model-1 (25-75%), Model-2 (0-100%), Model-3 (25-100%) and Model-4 (0-75%). Analysis included subendocardial, subepicardial and global torsion and recoil rate (mean of subendocardial and subepicardial values).Objectives: Cardiovascular magnetic resonance feature tracking (CMR-FT) offers quantification of myocardial deformation from routine cine images. However, data using CMR-FT to quantify left ventricular (LV) torsion and diastolic recoil are not yet available. We therefore sought to evaluate the feasibility and reproducibility of CMR-FT to quantify LV torsion and peak recoil rate using an optimal anatomical approach.Results: Quantification of torsion and recoil rate was feasible in all subjects. There was no significant difference between the different models at rest. However, only Model-1 (25-75%) discriminated between rest and stress (Global Torsion: 2.7 ± 1.5 cm-1, 3.6±2.0°cm-1, 5.1 ±2.2° cm-1, p< 0.01; Global Recoil Rate: -30.1 ±11.1°cm-1s-1,-46.9=15.0°cm-1s-1, -68.9±32.3°cm-1, p<0.01; for rest, 10 and 20 μg•kg-1•min-1 of dobutamine, respectively). Reproducibility was sufficient for all parameters as determined by Bland-Altman analysis, intraclass correlation coefficients and coefficient of variation.Conclusions: CMR-FT based derivation of myocardial torsion and recoil rate is feasible and reproducible at rest and with dobutamine stress. Using an optimal anatomical approach measuring rotation at 25% and 75% apical and basal LV locations allows effective quantification of torsion and recoil dynamics. Application of these new measures of deformation by CMR-FT should next be explored in disease states.
AB - Methods: Short-axis cine stacks were acquired at rest and during dobutamine stimulation (10 and 20 μg•kg-1•min-1) in 10 healthy volunteers. Rotational displacement was analysed for all slices. A complete 3D-LV rotational model was developed using linear interpolation between adjacent slices. Torsion was defined as the difference between apical and basal rotation, divided by slice distance. Depending on the distance between the most apical (defined as 0% LV distance) and basal (defined as 100% LV distance) slices, four different models for the calculation of torsion were examined: Model-1 (25-75%), Model-2 (0-100%), Model-3 (25-100%) and Model-4 (0-75%). Analysis included subendocardial, subepicardial and global torsion and recoil rate (mean of subendocardial and subepicardial values).Objectives: Cardiovascular magnetic resonance feature tracking (CMR-FT) offers quantification of myocardial deformation from routine cine images. However, data using CMR-FT to quantify left ventricular (LV) torsion and diastolic recoil are not yet available. We therefore sought to evaluate the feasibility and reproducibility of CMR-FT to quantify LV torsion and peak recoil rate using an optimal anatomical approach.Results: Quantification of torsion and recoil rate was feasible in all subjects. There was no significant difference between the different models at rest. However, only Model-1 (25-75%) discriminated between rest and stress (Global Torsion: 2.7 ± 1.5 cm-1, 3.6±2.0°cm-1, 5.1 ±2.2° cm-1, p< 0.01; Global Recoil Rate: -30.1 ±11.1°cm-1s-1,-46.9=15.0°cm-1s-1, -68.9±32.3°cm-1, p<0.01; for rest, 10 and 20 μg•kg-1•min-1 of dobutamine, respectively). Reproducibility was sufficient for all parameters as determined by Bland-Altman analysis, intraclass correlation coefficients and coefficient of variation.Conclusions: CMR-FT based derivation of myocardial torsion and recoil rate is feasible and reproducible at rest and with dobutamine stress. Using an optimal anatomical approach measuring rotation at 25% and 75% apical and basal LV locations allows effective quantification of torsion and recoil dynamics. Application of these new measures of deformation by CMR-FT should next be explored in disease states.
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U2 - 10.1371/journal.pone.0109164
DO - 10.1371/journal.pone.0109164
M3 - Article
C2 - 25285656
AN - SCOPUS:84907689699
SN - 1932-6203
VL - 9
JO - PloS one
JF - PloS one
IS - 10
M1 - e109164
ER -