Quantification of nitric oxide concentration using single-walled carbon nanotube sensors

Jakob Meier, Joseph Stapleton, Eric Hofferber, Abigail Haworth, Stephen Kachman, Nicole M. Iverson

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Nitric oxide (NO), a free radical present in biological systems, can have many detrimental effects on the body, from inflammation to cancer. Due to NO’s short half-life, detection and quan-tification is difficult. The inability to quantify NO has hindered researchers’ understanding of its impact in healthy and diseased conditions. Single-walled carbon nanotubes (SWNTs), when wrapped in a specific single-stranded DNA chain, becomes selective to NO, creating a fluorescence sensor. Unfortunately, the correlation between NO concentration and the SWNT’s fluorescence intensity has been difficult to determine due to an inability to immobilize the sensor without altering its properties. Through the use of a recently developed sensor platform, systematic studies can now be conducted to determine the correlation between SWNT fluorescence and NO concentration. This paper explains the methods used to determine the equations that can be used to convert SWNT fluorescence into NO concentration. Through the use of the equations developed in this paper, an easy method for NO quantification is provided. The methods outlined in this paper will also enable researchers to develop equations to determine the concentration of other reactive species through the use of SWNT sensors.

Original languageEnglish (US)
Article number243
Pages (from-to)1-9
Number of pages9
JournalNanomaterials
Volume11
Issue number1
DOIs
StatePublished - Jan 2021

Keywords

  • Carbon nanotube sensors
  • Concentration quantification
  • Nitric oxide
  • Reactive species
  • Spatial detection
  • Temporal detection

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Materials Science(all)

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