Quantitative diffusion tensor imaging detects dopaminergic neuronal degeneration in a murine model of Parkinson's disease

Michael D. Boska, Khader M. Hasan, Danette Kibuule, Rebecca Banerjee, Erin McIntyre, Jay A. Nelson, Theresa Hahn, Howard E. Gendelman, R. Lee Mosley

Research output: Contribution to journalArticle

95 Scopus citations

Abstract

Early diagnosis of Parkinson's disease (PD) is required to improve therapeutic responses. Indeed, a clinical diagnosis of resting tremor, rigidity, movement and postural deficiencies usually reflect > 50% loss of the nigrostriatal system in disease. In a step to address this, quantitative diffusion tensor magnetic resonance imaging (DTI) was used to assess nigrostriatal degeneration in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) intoxication model of dopaminergic nigral degeneration. We now demonstrate increased average diffusion (p < 0.005) and decreased fractional anisotropy (p < 0.03) in the substantia nigra (SN) of 5- to 7-day MPTP-treated animals when compared to saline controls. Transverse diffusivity demonstrated the most significant differences (p ≤ 0.002) and correlated with the numbers of SN dopaminergic neurons (r = - 0.75, p = 0.012). No differences were found in the striatum, corpus callosum, cerebral cortex, or ventricles. These results demonstrate that DTI may be used as a surrogate biomarker of nigral dopaminergic neuronal degeneration.

Original languageEnglish (US)
Pages (from-to)590-596
Number of pages7
JournalNeurobiology of Disease
Volume26
Issue number3
DOIs
StatePublished - Jun 2007

Keywords

  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
  • Diffusion tensor imaging
  • Dopaminergic neurons
  • MPTP
  • Parkinson's disease
  • Striatum
  • Substantia nigra

ASJC Scopus subject areas

  • Neurology

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