Quantitative evaluation of inflammation in biopsy specimens from idiopathically failing or irritable hearts: Experience in 80 pediatric and adult patients

Randal S. Cassling; James Linder; Thomas D. Sears; Bruce F. Waller; William C. Rogler; Janet E. Wilson; John D. Kugler; David H. Kay; James C. Dillon; John D. Slack; Bruce M. McManus

doi:10.1016/0002-8703(85)90447-8

Quantitative evaluation of inflammation in biopsy specimens from idiopathically failing or irritable hearts: Experience in 80 pediatric and adult patients

Randal S. Cassling, James Linder, Thomas D. Sears, Bruce F. Waller, William C. Rogler, Janet E. Wilson, John D. Kugler, David H. Kay, James C. Dillon, John D. Slack, Bruce M. McManus

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

The histologic criteria for the diagnosis of myocarditis on an endomyocardial biopsy specimen are troubled by varying institutional criteria and interobserver differences. A comprehensive approach to tissue evaluation including quantitative assessment of mononuclear cell populations enhances the accuracy and the specificity of the morphologic diagnosis. Future efforts to characterize the infiltrating cell lines in inflammatory conditions of the heart will aid in the ultimate refinement of therapeutic efficacy.

Original language	English (US)
Pages (from-to)	713-720
Number of pages	8
Journal	American Heart Journal
Volume	110
Issue number	4
DOIs	https://doi.org/10.1016/0002-8703(85)90447-8
State	Published - Oct 1985

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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Cassling, R. S., Linder, J., Sears, T. D., Waller, B. F., Rogler, W. C., Wilson, J. E., Kugler, J. D., Kay, D. H., Dillon, J. C., Slack, J. D., & McManus, B. M. (1985). Quantitative evaluation of inflammation in biopsy specimens from idiopathically failing or irritable hearts: Experience in 80 pediatric and adult patients. American Heart Journal, 110(4), 713-720. https://doi.org/10.1016/0002-8703(85)90447-8

Cassling, RS, Linder, J, Sears, TD, Waller, BF, Rogler, WC, Wilson, JE, Kugler, JD, Kay, DH, Dillon, JC, Slack, JD & McManus, BM 1985, 'Quantitative evaluation of inflammation in biopsy specimens from idiopathically failing or irritable hearts: Experience in 80 pediatric and adult patients', American Heart Journal, vol. 110, no. 4, pp. 713-720. https://doi.org/10.1016/0002-8703(85)90447-8

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abstract = "The histologic criteria for the diagnosis of myocarditis on an endomyocardial biopsy specimen are troubled by varying institutional criteria and interobserver differences. A comprehensive approach to tissue evaluation including quantitative assessment of mononuclear cell populations enhances the accuracy and the specificity of the morphologic diagnosis. Future efforts to characterize the infiltrating cell lines in inflammatory conditions of the heart will aid in the ultimate refinement of therapeutic efficacy.",

author = "Cassling, {Randal S.} and James Linder and Sears, {Thomas D.} and Waller, {Bruce F.} and Rogler, {William C.} and Wilson, {Janet E.} and Kugler, {John D.} and Kay, {David H.} and Dillon, {James C.} and Slack, {John D.} and McManus, {Bruce M.}",

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AU - Waller, Bruce F.

AU - Rogler, William C.

AU - Wilson, Janet E.

AU - Kugler, John D.

AU - Kay, David H.

AU - Dillon, James C.

AU - Slack, John D.

AU - McManus, Bruce M.

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AB - The histologic criteria for the diagnosis of myocarditis on an endomyocardial biopsy specimen are troubled by varying institutional criteria and interobserver differences. A comprehensive approach to tissue evaluation including quantitative assessment of mononuclear cell populations enhances the accuracy and the specificity of the morphologic diagnosis. Future efforts to characterize the infiltrating cell lines in inflammatory conditions of the heart will aid in the ultimate refinement of therapeutic efficacy.

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Quantitative evaluation of inflammation in biopsy specimens from idiopathically failing or irritable hearts: Experience in 80 pediatric and adult patients

Abstract

ASJC Scopus subject areas

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