Quantitative trait locus for reading disability on chromosome 6

Lon R. Cardon, Shelley D. Smith, David W. Fulker, William J. Kimberling, Bruce F. Pennington, John C. DeFries

Research output: Contribution to journalArticle

458 Scopus citations

Abstract

Interval mapping of data from two independent samples of sib pairs, at least one member of whom was reading disabled, revealed evidence for a quantitative trait locus (QTL) on chromosome 6. Results obtained from analyses of reading performance from 114 sib pairs genotyped for DNA markers localized the QTL to 6p21.3. Analyses of corresponding data from an independent sample of 50 dizygotic twin pairs provided evidence for linkage to the same region. In combination, the replicate samples yielded a χ2 value of 16.73 (P = 0.0002). Examination of twin and kindred siblings with more extreme deficits in reading performance yielded even stronger evidence for a QTL (χ2 = 27.35, P < 0.00001). The position of the QTL was narrowly defined with a 100:1 confidence interval to a 2-centimorgan region within the human leukocyte antigen complex.

Original languageEnglish (US)
Pages (from-to)276-279
Number of pages4
JournalScience
Volume266
Issue number5183
DOIs
StatePublished - Oct 14 1994

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    Cardon, L. R., Smith, S. D., Fulker, D. W., Kimberling, W. J., Pennington, B. F., & DeFries, J. C. (1994). Quantitative trait locus for reading disability on chromosome 6. Science, 266(5183), 276-279. https://doi.org/10.1126/science.7939663