TY - JOUR
T1 - Quantitative-trait locus for specific language and reading deficits on chromosome 6p
AU - Gayán, Javier
AU - Smith, Shelley D.
AU - Cherny, Stacey S.
AU - Cardon, Lon R.
AU - Fulker, David W.
AU - Brower, Amy M.
AU - Olson, Richard K.
AU - Pennington, Bruce F.
AU - DeFries, John C.
N1 - Funding Information:
This work was supported in part by program project and center grants from the NICHD (HD-11681 and HD-27802), by NIDA center grant DA-11015, and by NICHD grant R01 HD-22223. The contributions of staff members of the many Colorado school districts that participated in our research, and of the twins and their families, are gratefully acknowledged. We also thank Helen E. Datta and Terry Goldhammer for database management.
PY - 1999
Y1 - 1999
N2 - Reading disability (RD), or dyslexia, is a complex cognitive disorder manifested by difficulties in learning to read, in otherwise normal individuals. Individuals with RD manifest deficits in several reading and language skills. Previous research has suggested the existence of a quantitative-trait locus (QTL) for RD on the short arm of chromosome 6. In the present study, RD subjects' performance in several measures of word recognition and component skills of orthographic coding, phonological decoding, and phoneme awareness were individually subjected to QTL analysis, with a new sample of 126 sib pairs, by means of a multipoint mapping method and eight informative DNA markers on chromosome 6 (D6S461, D6S276, D6S105, D6S306, D6S258, D6S439, D6S291, and D6S1019). The results indicate significant linkage across a distance of at least 5 cM for deficits in orthographic (LOD = 3.10) and phonological (LOD = 2.42) skills, confirming previous findings.
AB - Reading disability (RD), or dyslexia, is a complex cognitive disorder manifested by difficulties in learning to read, in otherwise normal individuals. Individuals with RD manifest deficits in several reading and language skills. Previous research has suggested the existence of a quantitative-trait locus (QTL) for RD on the short arm of chromosome 6. In the present study, RD subjects' performance in several measures of word recognition and component skills of orthographic coding, phonological decoding, and phoneme awareness were individually subjected to QTL analysis, with a new sample of 126 sib pairs, by means of a multipoint mapping method and eight informative DNA markers on chromosome 6 (D6S461, D6S276, D6S105, D6S306, D6S258, D6S439, D6S291, and D6S1019). The results indicate significant linkage across a distance of at least 5 cM for deficits in orthographic (LOD = 3.10) and phonological (LOD = 2.42) skills, confirming previous findings.
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U2 - 10.1086/302191
DO - 10.1086/302191
M3 - Article
C2 - 9915954
AN - SCOPUS:0033364213
VL - 64
SP - 157
EP - 164
JO - American Journal of Human Genetics
JF - American Journal of Human Genetics
SN - 0002-9297
IS - 1
ER -