Quinolinate differentiates between forebrain and cerebellar NMDA receptors

Daniel T. Monaghan; J. A. Beaton

doi:10.1016/0014-2999(91)90134-C

Quinolinate differentiates between forebrain and cerebellar NMDA receptors

Daniel T. Monaghan, J. A. Beaton

Pharmacology & Experimental Neuroscience (PEN)

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

The potency of N-methyl-D-aspartate (NMDA), ibotenate, L-glutamate and quinolinate for inhibiting [³H]L-glutamate binding to rat brain NMDA receptors was determined by quantitative autoradiography. In contrast to NMDA, ibotenate and L-glutamate, quinolinate more potently displaced binding in forebrain regions than in the cerebellum. Of all drug-region combinations, only quinolinate affinity in the cerebellum was best described by a two-affinity component model (K_i = 24 and 275 μM; 45% high affinity). The cerebellum appears to contain a unique quinolinate-insensitive NMDA receptor subtype.

Original language	English (US)
Pages (from-to)	123-125
Number of pages	3
Journal	European Journal of Pharmacology
Volume	194
Issue number	1
DOIs	https://doi.org/10.1016/0014-2999(91)90134-C
State	Published - Feb 26 1991

Keywords

Autoradiography
Cerebellum
NMDA receptors
Quinolinate

ASJC Scopus subject areas

Pharmacology

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10.1016/0014-2999(91)90134-C

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title = "Quinolinate differentiates between forebrain and cerebellar NMDA receptors",

abstract = "The potency of N-methyl-D-aspartate (NMDA), ibotenate, L-glutamate and quinolinate for inhibiting [3H]L-glutamate binding to rat brain NMDA receptors was determined by quantitative autoradiography. In contrast to NMDA, ibotenate and L-glutamate, quinolinate more potently displaced binding in forebrain regions than in the cerebellum. Of all drug-region combinations, only quinolinate affinity in the cerebellum was best described by a two-affinity component model (Ki = 24 and 275 μM; 45% high affinity). The cerebellum appears to contain a unique quinolinate-insensitive NMDA receptor subtype.",

keywords = "Autoradiography, Cerebellum, NMDA receptors, Quinolinate",

author = "Monaghan, {Daniel T.} and Beaton, {J. A.}",

note = "Funding Information: This work was supported by NIH Grant NS 28966.",

year = "1991",

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T1 - Quinolinate differentiates between forebrain and cerebellar NMDA receptors

AU - Monaghan, Daniel T.

AU - Beaton, J. A.

N1 - Funding Information: This work was supported by NIH Grant NS 28966.

PY - 1991/2/26

Y1 - 1991/2/26

N2 - The potency of N-methyl-D-aspartate (NMDA), ibotenate, L-glutamate and quinolinate for inhibiting [3H]L-glutamate binding to rat brain NMDA receptors was determined by quantitative autoradiography. In contrast to NMDA, ibotenate and L-glutamate, quinolinate more potently displaced binding in forebrain regions than in the cerebellum. Of all drug-region combinations, only quinolinate affinity in the cerebellum was best described by a two-affinity component model (Ki = 24 and 275 μM; 45% high affinity). The cerebellum appears to contain a unique quinolinate-insensitive NMDA receptor subtype.

AB - The potency of N-methyl-D-aspartate (NMDA), ibotenate, L-glutamate and quinolinate for inhibiting [3H]L-glutamate binding to rat brain NMDA receptors was determined by quantitative autoradiography. In contrast to NMDA, ibotenate and L-glutamate, quinolinate more potently displaced binding in forebrain regions than in the cerebellum. Of all drug-region combinations, only quinolinate affinity in the cerebellum was best described by a two-affinity component model (Ki = 24 and 275 μM; 45% high affinity). The cerebellum appears to contain a unique quinolinate-insensitive NMDA receptor subtype.

KW - Autoradiography

KW - Cerebellum

KW - NMDA receptors

KW - Quinolinate

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Quinolinate differentiates between forebrain and cerebellar NMDA receptors

Abstract

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