Quinolinate differentiates between forebrain and cerebellar NMDA receptors

Daniel T. Monaghan, J. A. Beaton

Research output: Contribution to journalArticle

67 Scopus citations

Abstract

The potency of N-methyl-D-aspartate (NMDA), ibotenate, L-glutamate and quinolinate for inhibiting [3H]L-glutamate binding to rat brain NMDA receptors was determined by quantitative autoradiography. In contrast to NMDA, ibotenate and L-glutamate, quinolinate more potently displaced binding in forebrain regions than in the cerebellum. Of all drug-region combinations, only quinolinate affinity in the cerebellum was best described by a two-affinity component model (Ki = 24 and 275 μM; 45% high affinity). The cerebellum appears to contain a unique quinolinate-insensitive NMDA receptor subtype.

Original languageEnglish (US)
Pages (from-to)123-125
Number of pages3
JournalEuropean Journal of Pharmacology
Volume194
Issue number1
DOIs
StatePublished - Feb 26 1991

Keywords

  • Autoradiography
  • Cerebellum
  • NMDA receptors
  • Quinolinate

ASJC Scopus subject areas

  • Pharmacology

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