R-α-lipoic acid as a potent agent of mitochondrial protection in alzheimer’s disease

David J. Bonda, Mark A. Smith, George Perry, Hyoung Gon Lee, Xinglong Wang, Xiongwei Zhu

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Alzheimer’s disease (AD) is a chronic neurodegenerative condition that gradually reduces a patient’s learning ability, memory, language ability, communication skills, and high-level cognition. Its incidence begins in the parahippocampal formation (i.e., the entorhinal cortex) and pathologically spreads into the hippocampal region (i.e., the dentate gyrus and CA1/3) and eventually into the cortex and beyond (Castellani, Rolston, and Smith 2010). Clinical symptoms of AD begin as a mild dementia and progress until the patient is unable to care for him/herself; even at the earliest clinical stages, the pathological deterioration of the affected brain regions is likely considerably underway. It is therefore crucial that we recognize and attenuate early risk factors for AD before symptoms become clinically manifest.

Original languageEnglish (US)
Title of host publicationMitochondrial Signaling in Health and Disease
PublisherCRC Press
Pages455-467
Number of pages13
ISBN (Electronic)9781439880036
ISBN (Print)9781439880029
StatePublished - Jan 1 2012
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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