Rabs and EHDs: Alternate modes for traffic control

Research output: Contribution to journalReview article

15 Scopus citations

Abstract

Endocytic trafficking is a highly organized process regulated by a network of proteins, including the Rab family of small GTP-binding proteins and the C-terminal EHDs (Eps15 homology-domain-containing proteins). Central roles for Rab proteins have been described in vesicle budding, delivery, tethering and fusion, whereas little is known about the functions of EHDs in membrane transport. Common effectors for these two protein families have been identified, and they facilitate regulation of sequential steps in transport. By comparing and contrasting key aspects in their modes of function, we shall promote a better understanding of how Rab proteins and EHDs regulate endocytic trafficking.

Original languageEnglish (US)
Pages (from-to)17-23
Number of pages7
JournalBioscience Reports
Volume32
Issue number1
DOIs
StatePublished - Feb 1 2012

Keywords

  • Collapsin response mediator protein-2 (CRMP2)
  • Endocytic trafficking
  • Eps15 homology (EH)
  • Eps15 homology-domain-containing protein (EHD)
  • GTPase-activating protein (GAP)
  • Rab
  • Transferrin receptor (TfR)

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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