Racial differences in the frequency of Q and C chromosomal heteromorphisms

H. A. Lubs, W. J. Kimberling, F. Hecht, S. R. Patil, J. Brown, P. Gerald, R. L. Summitt

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

THE biological and clinical implications of human chromosome heteromorphisms are poorly understood. These heteromorphisms are limited to certain groups, and are heritable1. Consistent variability between people, in both size and staining properties, is observed. This may reflect either structural or biochemical variations. Before chromosome banding procedures, the length of the Y was known to vary from person to person and from one ethnic group to another2. Some autosomal regions were also found to differ in various racial groups3,4. Using Q- and C-banding procedures, we have regions scored were (1) on the long arms (qh) of chromosomes 1,9 and 16; (2) on the short arms (P) of the acrocentric autosomes (13-15 and 21-22); and (3) on the centromere (c) of all other chromosomes. The results indicate significant differences between the samples of black and white children.

Original languageEnglish (US)
Pages (from-to)631-633
Number of pages3
JournalNature
Volume268
Issue number5621
DOIs
StatePublished - 1977

ASJC Scopus subject areas

  • General

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