TY - JOUR
T1 - Radioiododemercuration
T2 - a simple synthesis of 5-[123/125/127I]iodo-2′-deoxyuridine
AU - Baranowska-Kortylewicz, Janina
AU - Kinsey, Berma M.
AU - Layne, Warren W.
AU - Kassis, Amin I.
N1 - Funding Information:
Acknowledgements--This work was supported in part by USPHS Grant CA 15523-13. JBK is a research fellow under Radiation Biology Training Program NIH 5T32 CA 09078-I 1.
PY - 1988
Y1 - 1988
N2 - Through the use of iododemercuration, 5-[123/125I]iodo-2′-deoxyuridine was synthesized rapidly and with high radiochemical purity from 5-chloromercuri-2′-deoxyuridine. The synthesis of radioiodinated 2′-deoxyuridine was achieved in one step in the presence of Iodogen in 50% yield after isolation by reverse phase high performance column chromatography. The radiochemical purity was greater than 99%. The ease and rapidity of both preparation and isolation of no-carrier-added 5-[123/125I]iodo-2′-deoxyuridine, as well as the absence of any starting material, suggests that radiohalodemercuration may be the method of choice for this and structurally similar compounds.
AB - Through the use of iododemercuration, 5-[123/125I]iodo-2′-deoxyuridine was synthesized rapidly and with high radiochemical purity from 5-chloromercuri-2′-deoxyuridine. The synthesis of radioiodinated 2′-deoxyuridine was achieved in one step in the presence of Iodogen in 50% yield after isolation by reverse phase high performance column chromatography. The radiochemical purity was greater than 99%. The ease and rapidity of both preparation and isolation of no-carrier-added 5-[123/125I]iodo-2′-deoxyuridine, as well as the absence of any starting material, suggests that radiohalodemercuration may be the method of choice for this and structurally similar compounds.
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U2 - 10.1016/0883-2889(88)90026-3
DO - 10.1016/0883-2889(88)90026-3
M3 - Article
C2 - 2838439
AN - SCOPUS:0023855792
SN - 0883-2889
VL - 39
SP - 335
EP - 341
JO - International Journal of Radiation Applications and Instrumentation. Part
JF - International Journal of Radiation Applications and Instrumentation. Part
IS - 4
ER -