Through the use of iododemercuration, 5-[123/125I]iodo-2′-deoxyuridine was synthesized rapidly and with high radiochemical purity from 5-chloromercuri-2′-deoxyuridine. The synthesis of radioiodinated 2′-deoxyuridine was achieved in one step in the presence of Iodogen in 50% yield after isolation by reverse phase high performance column chromatography. The radiochemical purity was greater than 99%. The ease and rapidity of both preparation and isolation of no-carrier-added 5-[123/125I]iodo-2′-deoxyuridine, as well as the absence of any starting material, suggests that radiohalodemercuration may be the method of choice for this and structurally similar compounds.
|Original language||English (US)|
|Number of pages||7|
|Journal||International Journal of Radiation Applications and Instrumentation. Part|
|State||Published - 1988|
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