Radiolabeling kit/generator for 5‐radiohalogenated uridines

Janina Baranowska‐Kortylewicz, Lynn D. Helseth, Jing Lai, Martin H. Schneiderman, G. Sue Schneiderman, Glenn V. Dalrymple

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

A rapid, simple and inexpensive synthesis of 5‐radiohalogenated‐2′‐deoxyuridine from 5‐trimethylstannyl‐2′‐deoxyuridine is described. The total reaction and purification time including thin layer chromatography (tlc) for quality control is less than 30 min. This method produces excellent yields (>95%) of 123I‐, 125I‐, 131I‐UdR. The radiochemical purity of all tested preparations (>20) was determined to be greater than 99%. This new method is the basis of a radiolabeling kit/generator for preparation of radiohalogenated nucleosides. 2′‐Deoxyuridine (UdR) halogenated with a stable isotope of bromine was also synthesized indicating that the method can be applied to the preparation of 5‐radiobromo‐2′‐deoxyuridine (BUdR).

Original languageEnglish (US)
Pages (from-to)513-521
Number of pages9
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume34
Issue number6
DOIs
StatePublished - Jun 1994

Keywords

  • 5‐iodo‐2′‐deoxyuridine
  • iodine
  • radioisotopes
  • radiolabeling kit/generator

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

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