Radiolabeling kit/generator for 5‐radiohalogenated uridines

Janina Baranowska‐Kortylewicz; Lynn D. Helseth; Jing Lai; Martin H. Schneiderman; G. Sue Schneiderman; Glenn V. Dalrymple

doi:10.1002/jlcr.2580340604

Radiolabeling kit/generator for 5‐radiohalogenated uridines

Janina Baranowska‐Kortylewicz, Lynn D. Helseth, Jing Lai, Martin H. Schneiderman, G. Sue Schneiderman, Glenn V. Dalrymple

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

A rapid, simple and inexpensive synthesis of 5‐radiohalogenated‐2′‐deoxyuridine from 5‐trimethylstannyl‐2′‐deoxyuridine is described. The total reaction and purification time including thin layer chromatography (tlc) for quality control is less than 30 min. This method produces excellent yields (>95%) of ¹²³I‐, ¹²⁵I‐, ¹³¹I‐UdR. The radiochemical purity of all tested preparations (>20) was determined to be greater than 99%. This new method is the basis of a radiolabeling kit/generator for preparation of radiohalogenated nucleosides. 2′‐Deoxyuridine (UdR) halogenated with a stable isotope of bromine was also synthesized indicating that the method can be applied to the preparation of 5‐radiobromo‐2′‐deoxyuridine (BUdR).

Original language	English (US)
Pages (from-to)	513-521
Number of pages	9
Journal	Journal of Labelled Compounds and Radiopharmaceuticals
Volume	34
Issue number	6
DOIs	https://doi.org/10.1002/jlcr.2580340604
State	Published - Jun 1994

Keywords

5‐iodo‐2′‐deoxyuridine
iodine
radioisotopes
radiolabeling kit/generator

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Radiology Nuclear Medicine and imaging
Drug Discovery
Spectroscopy
Organic Chemistry

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10.1002/jlcr.2580340604

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title = "Radiolabeling kit/generator for 5‐radiohalogenated uridines",

abstract = "A rapid, simple and inexpensive synthesis of 5‐radiohalogenated‐2′‐deoxyuridine from 5‐trimethylstannyl‐2′‐deoxyuridine is described. The total reaction and purification time including thin layer chromatography (tlc) for quality control is less than 30 min. This method produces excellent yields (>95%) of 123I‐, 125I‐, 131I‐UdR. The radiochemical purity of all tested preparations (>20) was determined to be greater than 99%. This new method is the basis of a radiolabeling kit/generator for preparation of radiohalogenated nucleosides. 2′‐Deoxyuridine (UdR) halogenated with a stable isotope of bromine was also synthesized indicating that the method can be applied to the preparation of 5‐radiobromo‐2′‐deoxyuridine (BUdR).",

keywords = "5‐iodo‐2′‐deoxyuridine, iodine, radioisotopes, radiolabeling kit/generator",

author = "Janina Baranowska‐Kortylewicz and Helseth, {Lynn D.} and Jing Lai and Schneiderman, {Martin H.} and Schneiderman, {G. Sue} and Dalrymple, {Glenn V.}",

year = "1994",

month = jun,

doi = "10.1002/jlcr.2580340604",

language = "English (US)",

volume = "34",

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T1 - Radiolabeling kit/generator for 5‐radiohalogenated uridines

AU - Baranowska‐Kortylewicz, Janina

AU - Helseth, Lynn D.

AU - Lai, Jing

AU - Schneiderman, Martin H.

AU - Schneiderman, G. Sue

AU - Dalrymple, Glenn V.

PY - 1994/6

Y1 - 1994/6

N2 - A rapid, simple and inexpensive synthesis of 5‐radiohalogenated‐2′‐deoxyuridine from 5‐trimethylstannyl‐2′‐deoxyuridine is described. The total reaction and purification time including thin layer chromatography (tlc) for quality control is less than 30 min. This method produces excellent yields (>95%) of 123I‐, 125I‐, 131I‐UdR. The radiochemical purity of all tested preparations (>20) was determined to be greater than 99%. This new method is the basis of a radiolabeling kit/generator for preparation of radiohalogenated nucleosides. 2′‐Deoxyuridine (UdR) halogenated with a stable isotope of bromine was also synthesized indicating that the method can be applied to the preparation of 5‐radiobromo‐2′‐deoxyuridine (BUdR).

AB - A rapid, simple and inexpensive synthesis of 5‐radiohalogenated‐2′‐deoxyuridine from 5‐trimethylstannyl‐2′‐deoxyuridine is described. The total reaction and purification time including thin layer chromatography (tlc) for quality control is less than 30 min. This method produces excellent yields (>95%) of 123I‐, 125I‐, 131I‐UdR. The radiochemical purity of all tested preparations (>20) was determined to be greater than 99%. This new method is the basis of a radiolabeling kit/generator for preparation of radiohalogenated nucleosides. 2′‐Deoxyuridine (UdR) halogenated with a stable isotope of bromine was also synthesized indicating that the method can be applied to the preparation of 5‐radiobromo‐2′‐deoxyuridine (BUdR).

KW - 5‐iodo‐2′‐deoxyuridine

KW - iodine

KW - radioisotopes

KW - radiolabeling kit/generator

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DO - 10.1002/jlcr.2580340604

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SN - 0362-4803

VL - 34

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JO - Journal of Labelled Compounds and Radiopharmaceuticals

JF - Journal of Labelled Compounds and Radiopharmaceuticals

IS - 6

ER -

Radiolabeling kit/generator for 5‐radiohalogenated uridines

Abstract

Keywords

ASJC Scopus subject areas

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