TY - JOUR
T1 - Radiopharmaceuticals
T2 - When and how to use them to treat metastatic bone pain
AU - Paes, Fabio M.
AU - Ernani, Vinicius
AU - Hosein, Peter
AU - Serafini, Aldo N.
PY - 2011/11
Y1 - 2011/11
N2 - Bone pain due to skeletal metastases constitutes the most common type of cancer-related pain. The management of bone pain remains challenging and is not standardized. In patients with multifocal osteoblastic metastases, systemic radiopharmaceuticals should be the preferred adjunctive therapy for pain palliation. The lack of general knowledge about radiopharmaceuticals, their clinical utility and safety profiles, constitutes the major cause for their underutilization. Our goal is to review the indications, selection criteria, efficacy, and toxicities of two approved radiopharmaceuticals for bone pain palliation: strontium-89 and samarium-153. Finally, a brief review of the data on combination therapy with bisphosphonates or chemotherapy is included.
AB - Bone pain due to skeletal metastases constitutes the most common type of cancer-related pain. The management of bone pain remains challenging and is not standardized. In patients with multifocal osteoblastic metastases, systemic radiopharmaceuticals should be the preferred adjunctive therapy for pain palliation. The lack of general knowledge about radiopharmaceuticals, their clinical utility and safety profiles, constitutes the major cause for their underutilization. Our goal is to review the indications, selection criteria, efficacy, and toxicities of two approved radiopharmaceuticals for bone pain palliation: strontium-89 and samarium-153. Finally, a brief review of the data on combination therapy with bisphosphonates or chemotherapy is included.
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U2 - 10.1016/j.suponc.2011.06.004
DO - 10.1016/j.suponc.2011.06.004
M3 - Review article
C2 - 22055888
AN - SCOPUS:83455244321
SN - 1544-6794
VL - 9
SP - 197
EP - 205
JO - Journal of Supportive Oncology
JF - Journal of Supportive Oncology
IS - 6
ER -