Rapid effects of angiotensin-i I on polyphosphoinositide metabolism in the rat adrenal glomerulosa

Robert V. Farese; Ronald E. Larson; John S. Davis

doi:10.1210/endo-114-1-302

Rapid effects of angiotensin-i I on polyphosphoinositide metabolism in the rat adrenal glomerulosa

Robert V. Farese, Ronald E. Larson, John S. Davis

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Abstract

Angiotensin-1 I (A-ll) provoked a rapid decrease in ³²p jn triphosphoinositide (TPI) in ³²p-pre-labeled rat adrenal glomerulosa cells. This effect (presumably reflecting TPI hydrolysis) of A-ll was nearly maximal at 5 sec of incubation and appeared to precede increases in labeling of phosphatidic acid and phosphat idylinositol. Other aldosterone-stimulating agents (ACTH, K⁺ and serotonin) did not provoke this effect. Since this effect appeared to be independent of Ca⁺⁺, it is possible that TPI hydrolysis may be important for Ca ⁺⁺ mobilization during A-ll action in glomerulosa tissue.

Original language	English (US)
Pages (from-to)	302-304
Number of pages	3
Journal	Endocrinology
Volume	114
Issue number	1
DOIs	https://doi.org/10.1210/endo-114-1-302
State	Published - 1984
Externally published	Yes

ASJC Scopus subject areas

Endocrinology

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title = "Rapid effects of angiotensin-i I on polyphosphoinositide metabolism in the rat adrenal glomerulosa",

abstract = "Angiotensin-1 I (A-ll) provoked a rapid decrease in 32p jn triphosphoinositide (TPI) in 32p-pre-labeled rat adrenal glomerulosa cells. This effect (presumably reflecting TPI hydrolysis) of A-ll was nearly maximal at 5 sec of incubation and appeared to precede increases in labeling of phosphatidic acid and phosphat idylinositol. Other aldosterone-stimulating agents (ACTH, K+ and serotonin) did not provoke this effect. Since this effect appeared to be independent of Ca++, it is possible that TPI hydrolysis may be important for Ca ++ mobilization during A-ll action in glomerulosa tissue.",

author = "Farese, {Robert V.} and Larson, {Ronald E.} and Davis, {John S.}",

year = "1984",

doi = "10.1210/endo-114-1-302",

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AU - Farese, Robert V.

AU - Larson, Ronald E.

AU - Davis, John S.

PY - 1984

Y1 - 1984

N2 - Angiotensin-1 I (A-ll) provoked a rapid decrease in 32p jn triphosphoinositide (TPI) in 32p-pre-labeled rat adrenal glomerulosa cells. This effect (presumably reflecting TPI hydrolysis) of A-ll was nearly maximal at 5 sec of incubation and appeared to precede increases in labeling of phosphatidic acid and phosphat idylinositol. Other aldosterone-stimulating agents (ACTH, K+ and serotonin) did not provoke this effect. Since this effect appeared to be independent of Ca++, it is possible that TPI hydrolysis may be important for Ca ++ mobilization during A-ll action in glomerulosa tissue.

AB - Angiotensin-1 I (A-ll) provoked a rapid decrease in 32p jn triphosphoinositide (TPI) in 32p-pre-labeled rat adrenal glomerulosa cells. This effect (presumably reflecting TPI hydrolysis) of A-ll was nearly maximal at 5 sec of incubation and appeared to precede increases in labeling of phosphatidic acid and phosphat idylinositol. Other aldosterone-stimulating agents (ACTH, K+ and serotonin) did not provoke this effect. Since this effect appeared to be independent of Ca++, it is possible that TPI hydrolysis may be important for Ca ++ mobilization during A-ll action in glomerulosa tissue.

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Rapid effects of angiotensin-i I on polyphosphoinositide metabolism in the rat adrenal glomerulosa

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