Rat embryo development in vitro

S. K. Roy, J. Sengupta, S. K. Manchanda

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


We report the first successful culture of 8-cell/morula stage rat embryos in a fully synthetic medium supplemented with 3% crystalline bovine serum albumin. Eighty-four per cent of morulae developed to blastocysts, showing that this is a highly efficient culture medium for in vitro studies on rat pre-implantation embryos. Blastocyst formation was severely inhibited by antioestrogen (nafoxidine 3 μg/ml) but no further reversal was obtained by giving oestrogen to culture medium containing this antagonist.

Original languageEnglish (US)
Pages (from-to)546-551
Number of pages6
JournalActa Endocrinologica
Issue number4
StatePublished - 1981
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology


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