Rational design of nanofiber scaffolds for orthopedic tissue repair and regeneration

Bing Ma, Jingwei Xie, Jiang Jiang, Franklin D. Shuler, David E. Bartlett

Research output: Contribution to journalReview article

43 Scopus citations

Abstract

This article reviews recent significant advances in the design of nanofiber scaffolds for orthopedic tissue repair and regeneration. It begins with a brief introduction on the limitations of current approaches for orthopedic tissue repair and regeneration. It then illustrates that rationally designed scaffolds made up of electrospun nanofibers could be a promising solution to overcome the problems that current approaches encounter. The article also discusses the intriguing properties of electrospun nanofibers, including control of composition, structures, orders, alignments and mechanical properties, use as carriers for topical drug and/or gene sustained delivery, and serving as substrates for the regulation of cell behaviors, which could benefit musculoskeletal tissue repair and regeneration. It further highlights a few of the many recent applications of electrospun nanofiber scaffolds in repairing and regenerating various orthopedic tissues. Finally, the article concludes with perspectives on the challenges and future directions for better design, fabrication and utilization of nanofiber scaffolds for orthopedic tissue engineering.

Original languageEnglish (US)
Pages (from-to)1459-1481
Number of pages23
JournalNanomedicine
Volume8
Issue number9
DOIs
StatePublished - Sep 2013

Keywords

  • design
  • electrospinning
  • nanofiber scaffold
  • orthopedic tissue
  • regeneration
  • repair
  • tissue engineering

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Materials Science(all)

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