Reactions between activated Benzo[a]pyrene and nucleophilic compounds, with possible implications on the mechanism of tumor initiation

E. Cavalieri, R. Auerbach

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Abstract

Benzo[a]pyrene activated by one-electron oxidation with iodine or ferric ion (an essential component of cytochrome P-450), or by a presumed electrophilic oxygen obtained from the model system ferric chloride and hydrogen peroxide produced cationic species which on subsequent trapping with suitable nucleophiles gave only 6-substituted benzopyrenes. The results implied an appreciable degree of positive-charge localization at the 6-carbon atom in the reactive intermediates of the carcinogenic compound.

Original languageEnglish (US)
Pages (from-to)393-397
Number of pages5
JournalJournal of the National Cancer Institute
Volume53
Issue number2
DOIs
StatePublished - Aug 1974

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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