TY - JOUR
T1 - Reactive oxygen species drive epigenetic changes in radiation-induced fibrosis
AU - Shrishrimal, Shashank
AU - Kosmacek, Elizabeth A.
AU - Oberley-Deegan, Rebecca E.
N1 - Funding Information:
This study is supported by National Institutes of Health Grants 1R01CA178888 and NIH SP20 GM103480 COBRE and Fred & Pamela Buffett Cancer Center Support Grant P30CA036727.
Publisher Copyright:
© 2019 Shashank Shrishrimal et al.
PY - 2019
Y1 - 2019
N2 - Radiation-induced fibrosis (RIF) develops months to years after initial radiation exposure. RIF occurs when normal fibroblasts differentiate into myofibroblasts and lay down aberrant amounts of extracellular matrix proteins. One of the main drivers for developing RIF is reactive oxygen species (ROS) generated immediately after radiation exposure. Generation of ROS is known to induce epigenetic changes and cause differentiation of fibroblasts to myofibroblasts. Several antioxidant compounds have been shown to prevent radiation-induced epigenetic changes and the development of RIF. Therefore, reviewing the ROS-linked epigenetic changes in irradiated fibroblast cells is essential to understand the development and prevention of RIF.
AB - Radiation-induced fibrosis (RIF) develops months to years after initial radiation exposure. RIF occurs when normal fibroblasts differentiate into myofibroblasts and lay down aberrant amounts of extracellular matrix proteins. One of the main drivers for developing RIF is reactive oxygen species (ROS) generated immediately after radiation exposure. Generation of ROS is known to induce epigenetic changes and cause differentiation of fibroblasts to myofibroblasts. Several antioxidant compounds have been shown to prevent radiation-induced epigenetic changes and the development of RIF. Therefore, reviewing the ROS-linked epigenetic changes in irradiated fibroblast cells is essential to understand the development and prevention of RIF.
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U2 - 10.1155/2019/4278658
DO - 10.1155/2019/4278658
M3 - Review article
C2 - 30881591
AN - SCOPUS:85063272510
VL - 2019
JO - Oxidative Medicine and Cellular Longevity
JF - Oxidative Medicine and Cellular Longevity
SN - 1942-0900
M1 - 4278658
ER -