Reactive oxygen species in chronic obstructive pulmonary disease

Samia Boukhenouna, Mark A. Wilson, Karim Bahmed, Beata Kosmider

Research output: Contribution to journalReview article

40 Scopus citations

Abstract

Chronic obstructive pulmonary disease (COPD) includes chronic bronchitis and emphysema. Environmental exposure, primarily cigarette smoking, can cause high oxidative stress and is the main factor of COPD development. Cigarette smoke also contributes to the imbalance of oxidant/antioxidant due to exogenous reactive oxygen species (ROS). Moreover, endogenously released ROS during the inflammatory process and mitochondrial dysfunction may contribute to this disease progression. ROS and reactive nitrogen species (RNS) can oxidize different biomolecules such as DNA, proteins, and lipids leading to epithelial cell injury and death. Various detoxifying enzymes and antioxidant defense systems can be involved in ROS removal. In this review, we summarize the main findings regarding the biological role of ROS, which may contribute to COPD development, and cytoprotective mechanisms against this disease progression.

Original languageEnglish (US)
Article number5730395
JournalOxidative medicine and cellular longevity
Volume2018
DOIs
StatePublished - 2018

ASJC Scopus subject areas

  • Biochemistry
  • Aging
  • Cell Biology

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