Reading disability, immune disorders and non-right-handedness: Twin and family studies of their relations

Jeffrey W. Gilger, Bruce F. Pennington, Phyllis Green, Sandra M. Smith, Shelley D. Smith

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

Geschwind and colleagues discussed associations among learning disorders, immune disorders and non-right-handedness. In this study, we examined the associations between reading disability (RD) and both immune disorders (ID) and non-right-handedness (NRH) in family and twin samples (total N = 1731 cases) identified through an RD proband. We also conducted co-segregation analyses to ascertain the degree to which NRH, ID and RD were biologically related. There was little evidence for an overall association between RD and NRH. There was not convergent evidence across all four samples for an association between RD and ID, although we did find an association between RD and ID in two of four samples. Nor was there strong support for a subtype where RD and NRH, or RD and ID, co-segregate in families. These data suggest that the associations postulated by Geschwind and colleagues are not robust in RD samples, although we cannot completely rule out the possibility of an RD plus ID subtype.

Original languageEnglish (US)
Pages (from-to)209-227
Number of pages19
JournalNeuropsychologia
Volume30
Issue number3
DOIs
StatePublished - Mar 1992

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

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