Reading disability, immune disorders and non-right-handedness: Twin and family studies of their relations

Jeffrey W. Gilger; Bruce F. Pennington; Phyllis Green; Sandra M. Smith; Shelley D. Smith

doi:10.1016/0028-3932(92)90001-3

Reading disability, immune disorders and non-right-handedness: Twin and family studies of their relations

Jeffrey W. Gilger, Bruce F. Pennington, Phyllis Green, Sandra M. Smith, Shelley D. Smith

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

Geschwind and colleagues discussed associations among learning disorders, immune disorders and non-right-handedness. In this study, we examined the associations between reading disability (RD) and both immune disorders (ID) and non-right-handedness (NRH) in family and twin samples (total N = 1731 cases) identified through an RD proband. We also conducted co-segregation analyses to ascertain the degree to which NRH, ID and RD were biologically related. There was little evidence for an overall association between RD and NRH. There was not convergent evidence across all four samples for an association between RD and ID, although we did find an association between RD and ID in two of four samples. Nor was there strong support for a subtype where RD and NRH, or RD and ID, co-segregate in families. These data suggest that the associations postulated by Geschwind and colleagues are not robust in RD samples, although we cannot completely rule out the possibility of an RD plus ID subtype.

Original language	English (US)
Pages (from-to)	209-227
Number of pages	19
Journal	Neuropsychologia
Volume	30
Issue number	3
DOIs	https://doi.org/10.1016/0028-3932(92)90001-3
State	Published - Mar 1992

ASJC Scopus subject areas

Experimental and Cognitive Psychology
Cognitive Neuroscience
Behavioral Neuroscience

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10.1016/0028-3932(92)90001-3

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title = "Reading disability, immune disorders and non-right-handedness: Twin and family studies of their relations",

abstract = "Geschwind and colleagues discussed associations among learning disorders, immune disorders and non-right-handedness. In this study, we examined the associations between reading disability (RD) and both immune disorders (ID) and non-right-handedness (NRH) in family and twin samples (total N = 1731 cases) identified through an RD proband. We also conducted co-segregation analyses to ascertain the degree to which NRH, ID and RD were biologically related. There was little evidence for an overall association between RD and NRH. There was not convergent evidence across all four samples for an association between RD and ID, although we did find an association between RD and ID in two of four samples. Nor was there strong support for a subtype where RD and NRH, or RD and ID, co-segregate in families. These data suggest that the associations postulated by Geschwind and colleagues are not robust in RD samples, although we cannot completely rule out the possibility of an RD plus ID subtype.",

author = "Gilger, {Jeffrey W.} and Pennington, {Bruce F.} and Phyllis Green and Smith, {Sandra M.} and Smith, {Shelley D.}",

note = "Funding Information: A~kilo~I~dyemenfs~Duringp reparation of this article Dr Gilger was supported by a Fellowship in Developmental Psychobiology through the University of Colorado (MHl5442), and Dr Pennington was supported by a NIMH RSDA (MH00419) and project grants (MH38870), as well as by grants from the March of Dimes (12-135) and the Orton Dyslexia Society. The twin research reported in this paper was supported in part by NICHD Grant No. HD 11681. Dr Gilger was funded by a training fellowship in Psychiatric Genetics at the University of Iowa Medical Smzhoowl hile the Iowa Data were being collected (MHl46201-13, 12). Dr S. M. Smith was partially funded by the Delta Kappa Gamma Society. We would like to thank all of the families and school district staff that made the studies reported in this paper possible, as well as Drs Crowe, Richman and Hoover of the University of Iowa.",

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AU - Smith, Shelley D.

N1 - Funding Information: A~kilo~I~dyemenfs~Duringp reparation of this article Dr Gilger was supported by a Fellowship in Developmental Psychobiology through the University of Colorado (MHl5442), and Dr Pennington was supported by a NIMH RSDA (MH00419) and project grants (MH38870), as well as by grants from the March of Dimes (12-135) and the Orton Dyslexia Society. The twin research reported in this paper was supported in part by NICHD Grant No. HD 11681. Dr Gilger was funded by a training fellowship in Psychiatric Genetics at the University of Iowa Medical Smzhoowl hile the Iowa Data were being collected (MHl46201-13, 12). Dr S. M. Smith was partially funded by the Delta Kappa Gamma Society. We would like to thank all of the families and school district staff that made the studies reported in this paper possible, as well as Drs Crowe, Richman and Hoover of the University of Iowa.

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N2 - Geschwind and colleagues discussed associations among learning disorders, immune disorders and non-right-handedness. In this study, we examined the associations between reading disability (RD) and both immune disorders (ID) and non-right-handedness (NRH) in family and twin samples (total N = 1731 cases) identified through an RD proband. We also conducted co-segregation analyses to ascertain the degree to which NRH, ID and RD were biologically related. There was little evidence for an overall association between RD and NRH. There was not convergent evidence across all four samples for an association between RD and ID, although we did find an association between RD and ID in two of four samples. Nor was there strong support for a subtype where RD and NRH, or RD and ID, co-segregate in families. These data suggest that the associations postulated by Geschwind and colleagues are not robust in RD samples, although we cannot completely rule out the possibility of an RD plus ID subtype.

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Reading disability, immune disorders and non-right-handedness: Twin and family studies of their relations

Abstract

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