Real-Time and Wireless Assessment of Adherence to Antiretroviral Therapy With Co-Encapsulated Ingestion Sensor in HIV-Infected Patients: A Pilot Study

Eric S. Daar, Marc I. Rosen, Yan Wang, Lisa Siqueiros, Jie Shen, Mario Guerrero, Di Xiong, John Dao, Todd Young, Katya Corado, Courtney V. Fletcher, Honghu Liu

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Adherence with antiretroviral therapy is important for preventing disease progression and HIV transmission. The co-encapsulated pill sensor system sends a signal through a cutaneous patch and allows real-time monitoring of pill ingestion. A 16-week pilot study used a sensor system in 15 HIV-infected individuals with real-time monitoring of pill-taking with a personalized short message system text. System acceptability was assessed by survey at weeks 4, 8, 12, and 16. Follow-up occurred in 80% of subjects through 8 weeks. The system effectively collected measures of pill ingestion, which triggered text message reminders. Only 2 of 14 participants stated that co-encapsulated pills were “unable to take” or “poorly tolerated.” At least 75% of respondents stated at each visit that the patch was very or somewhat comfortable. With regard to text message reminders, only 10–15% of the participants at any visit did not find the messages to be helpful. Larger studies will define the utility of this system to assess antiretroviral adherence relative to standard measures.

Original languageEnglish (US)
Pages (from-to)189-194
Number of pages6
JournalClinical and Translational Science
Volume13
Issue number1
DOIs
StatePublished - Jan 1 2020

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Fingerprint Dive into the research topics of 'Real-Time and Wireless Assessment of Adherence to Antiretroviral Therapy With Co-Encapsulated Ingestion Sensor in HIV-Infected Patients: A Pilot Study'. Together they form a unique fingerprint.

  • Cite this

    Daar, E. S., Rosen, M. I., Wang, Y., Siqueiros, L., Shen, J., Guerrero, M., Xiong, D., Dao, J., Young, T., Corado, K., Fletcher, C. V., & Liu, H. (2020). Real-Time and Wireless Assessment of Adherence to Antiretroviral Therapy With Co-Encapsulated Ingestion Sensor in HIV-Infected Patients: A Pilot Study. Clinical and Translational Science, 13(1), 189-194. https://doi.org/10.1111/cts.12701