Real-time dobutamine stress myocardial perfusion echocardiography predicts outcome in the elderly

Jeane M. Tsutsui, Feng Xie, David Cloutier, Saul Kalvaitis, Abdou Elhendy, Thomas R. Porter

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Aims: Although there is an increasing number of studies showing the value of perfusion imaging with real-time contrast echocardiography (RTCE) for detecting coronary artery disease (CAD), no data exist regarding the value of this technique for detecting CAD and predicting outcome in the elderly. Methods and results: We examined the outcome of 399 patients ≥70 years old who underwent dobutamine stress RTCE for known or suspected CAD. Myocardial perfusion imaging (MPI) was performed using low mechanical index pulse sequence schemes following intravenous small bolus injections of ultrasound contrast. Quantitative coronary angiography (QCA) was performed within 1 month of the stress test in 60 patients. Events were defined as cardiac death or non-fatal myocardial infarction (MI). Sensitivity of MPI for detecting CAD by QCA was 94% [confidence interval (CI) 91-99], specificity was 67% (CI 36-74), and accuracy was 90% (CI 82-95). During a median follow-up of 21 months, 46 events occurred (31 cardiac deaths, 15 non-fatal MI). Univariate predictors of outcome were diuretic use (P = 0.03), abnormal stress wall motion (P < 0.0001), and abnormal stress MPI (P < 0.0001). Abnormal stress MPI, however, was the most significant predictor of outcome (χ2 7.5; P = 0.006). Conclusion: Myocardial perfusion analysis during dobutamine stress RTCE provides incremental predictive value in determining the outcome of elderly patients being evaluated for the presence of CAD.

Original languageEnglish (US)
Pages (from-to)377-385
Number of pages9
JournalEuropean Heart Journal
Issue number3
StatePublished - Feb 2008


  • Coronary artery disease
  • Elderly
  • Myocardial contrast echocardiography
  • Prognosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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