Real-time monitoring of cardiovascular function in rhesus macaques infected with zaire ebolavirus

Mark G. Kortepeter, James V. Lawler, Anna Honko, Mike Bray, Joshua C. Johnson, Bret K. Purcell, Gene G. Olinger, Robert Rivard, Matthew J. Hepburn, Lisa E. Hensley

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Nine rhesus macaques were implanted with multisensor telemetry devices and internal jugular vein catheters before being infected with Zaire ebolavirus. All animals developed viremia, fever, a hemorrhagic rash, and typical changes of Ebola hemorrhagic fever in clinical laboratory tests. Three macaques unexpectedly survived this usually lethal disease, making it possible to compare physiological parameters in lethally challenged animals and survivors. After the onset of fever, lethal illness was characterized by a decline in mean arterial blood pressure, an increase in pulse and respiratory rate, lactic acidosis, and renal failure. Survivors showed less pronounced change in these parameters. Four macaques were randomized to receive supplemental volumes of intravenous normal saline when they became hypotensive. Although those animals had less severe renal compromise, no apparent survival benefit was observed. This is the first report of continuous physiologic monitoring in filovirus-infected nonhuman primates and the first to attempt cardiovascular support with intravenous fluids.

Original languageEnglish (US)
Pages (from-to)S1000-S1010
JournalJournal of Infectious Diseases
Volume204
Issue numberSUPPL. 3
DOIs
StatePublished - Nov 1 2011

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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