Real-time two-dimensional imaging of microbubble cavitation

Francois Vignon, W. T. Shi, J. E. Powers, J. Liu, L. Drvol, J. Lof, C. Everbach, S. Gao, F. Xie, T. Porter

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Ultrasound cavitation of microbubble contrast agents has a potential for therapeutic applications, including sonothrombolysis in acute ischemic stroke. For safety, efficacy, and reproducibility of treatment, it is critical to evaluate the cavitation state (e.g. stable versus inertial forms of cavitation) and intensity in and around a treatment area. Acoustic Passive Cavitation Detectors (PCDs) have been used but do not provide spatial information. This paper presents a prototype of a 2D cavitation imager capable of producing images of the dominant cavitation state and intensity in a region of interest at a frame rate of 0.6Hz. The system is based on a modified ultrasound scanner (iE33, Philips) with a sector imaging probe (S5-1). Cavitation imaging is based on the spectral analysis of the acoustic signal radiated by the cavitating microbubbles: ultraharmonics of the excitation frequency indicate stable cavitation, while noise bands indicate inertial cavitation. The system demonstrates the capability to robustly identify stable and inertial cavitation thresholds of Definity microbubbles (Lantheus) in a vessel phantom through 3 ex-vivo human temporal bones, as well as to spatially map cavitation activities.

Original languageEnglish (US)
Title of host publication11th International Symposium on Therapeutic Ultrasound
Pages407-413
Number of pages7
DOIs
StatePublished - 2012
Event11th International Symposium on Therapeutic Ultrasound, ISTU 2011 - New York, NY, United States
Duration: Apr 11 2011Apr 13 2011

Publication series

NameAIP Conference Proceedings
Volume1481
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference11th International Symposium on Therapeutic Ultrasound, ISTU 2011
CountryUnited States
CityNew York, NY
Period4/11/114/13/11

Keywords

  • Cavitation
  • Sonothrombolysis
  • Stroke
  • Treatment monitoring
  • Treatment planning
  • Ultrasound contrast agents

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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  • Cite this

    Vignon, F., Shi, W. T., Powers, J. E., Liu, J., Drvol, L., Lof, J., Everbach, C., Gao, S., Xie, F., & Porter, T. (2012). Real-time two-dimensional imaging of microbubble cavitation. In 11th International Symposium on Therapeutic Ultrasound (pp. 407-413). (AIP Conference Proceedings; Vol. 1481). https://doi.org/10.1063/1.4757369