Realistic and critical review of the state of systemic anti-microbial peptides

Guangshun Wang, Abraham Fikru Mechesso

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Antimicrobial peptide research remains active not only because of the growing antibiotic resistance problem but also our desire to understand the role of innate immune peptides in host defense. While numerous peptides are currently under active development for topical use, this article highlights peptides with systemic efficacy. The scaffolds of these peptides range from linear to cyclic forms. The neutropenic mouse model is well established to illustrate antimicrobial efficacy from direct killing. The majority of tests, however, are conducted using normal mice so that both direct antimicrobial and immune regulatory effects can be characterized.

Original languageEnglish (US)
Pages (from-to)91-105
Number of pages15
JournalADMET and DMPK
Issue number2
StatePublished - 2022


  • Antibiotics
  • Antimicrobial peptides
  • Intravenous injection
  • Mic
  • Pd
  • Peptide design
  • Pk
  • Systemic efficacy
  • Toxicity

ASJC Scopus subject areas

  • Chemistry (miscellaneous)
  • Medicine (miscellaneous)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)


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