TY - JOUR
T1 - Recalcitrant oral ulcers caused by calcium channel blockers
T2 - Diagnosis and treatment considerations
AU - Cohen, Donald M.
AU - Bhattacharyya, Indraneel
AU - Lydiatt, William M.
PY - 1999/11
Y1 - 1999/11
N2 - Background. Oral ulcers often pose a dilemma in diagnosis and treatment. Patients seen routinely in dental practices are frequently receiving multiple medications. The authors discuss the pathogenesis, clinical appearance and treatment of drug-induced oral ulcers. Case Descriptions. Two patients with recalcitrant painful oral ulcers caused by calcium channel blockers are described. These ulcers failed to heal despite repeated interventions, including surgery, laser ablation, and topical and systemic steroid therapy. Results of the histopathologic examinations were nonspecific. The patients were in a great deal of pain because of the initial failure to recognize the cause of these ulcers. Clinical Implications. A careful medical history, including a detailed list of medications received, is critical in identifying drug-induced oral ulcerations, especially when the ulcer is resistant to treatment and of indeterminate cause. To date, calcium channel blockers have not been reported to cause oral ulcerations.
AB - Background. Oral ulcers often pose a dilemma in diagnosis and treatment. Patients seen routinely in dental practices are frequently receiving multiple medications. The authors discuss the pathogenesis, clinical appearance and treatment of drug-induced oral ulcers. Case Descriptions. Two patients with recalcitrant painful oral ulcers caused by calcium channel blockers are described. These ulcers failed to heal despite repeated interventions, including surgery, laser ablation, and topical and systemic steroid therapy. Results of the histopathologic examinations were nonspecific. The patients were in a great deal of pain because of the initial failure to recognize the cause of these ulcers. Clinical Implications. A careful medical history, including a detailed list of medications received, is critical in identifying drug-induced oral ulcerations, especially when the ulcer is resistant to treatment and of indeterminate cause. To date, calcium channel blockers have not been reported to cause oral ulcerations.
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U2 - 10.14219/jada.archive.1999.0100
DO - 10.14219/jada.archive.1999.0100
M3 - Article
C2 - 10573941
AN - SCOPUS:0033220382
SN - 0002-8177
VL - 130
SP - 1611
EP - 1618
JO - Journal of the American Dental Association
JF - Journal of the American Dental Association
IS - 11
ER -