Recapitulating developmental mechanisms for retinal regeneration

Iqbal Ahmad, Pooja Teotia, Helen Erickson, Xiaohuan Xia

Research output: Contribution to journalReview article

Abstract

Degeneration of specific retinal neurons in diseases like glaucoma, age-related macular degeneration, and retinitis pigmentosa is the leading cause of irreversible blindness. Currently, there is no therapy to modify the disease-associated degenerative changes. With the advancement in our knowledge about the mechanisms that regulate the development of the vertebrate retina, the approach to treat blinding diseases through regenerative medicine appears a near possibility. Recapitulation of developmental mechanisms is critical for reproducibly generating cells in either 2D or 3D culture of pluripotent stem cells for retinal repair and disease modeling. It is the key for unlocking the neurogenic potential of Müller glia in the adult retina for therapeutic regeneration. Here, we examine the current status and potential of the regenerative medicine approach for the retina in the backdrop of developmental mechanisms.

Original languageEnglish (US)
Article number100824
JournalProgress in Retinal and Eye Research
DOIs
StateAccepted/In press - Jan 1 2019

Keywords

  • Development
  • Disease modeling
  • Organoid
  • Pluripotent stem cells
  • Regeneration
  • Retina

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

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