Recent Advances in Head and Neck Tumor Microenvironment–Based Therapy

Muzafar A Macha, Nissar A. Wani, Rais A. Ganai, Ajaz A. Bhat, Abid Hamid, Sheema Hashem, Mohammad Haris, Sham S. Chauhan, Mohammad A. Zargar, Surinder K. Batra

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Head and neck squamous cell carcinomas (HNSCCs) are a group of heterogeneous aggressive tumors affecting more than half a million patients worldwide annually. While the tobacco- and alcohol-associated HNSCC tumors are declining, human papillomavirus (HPV)-induced tumors are on rise. Despite recent advances in multimodality therapeutic interventions including surgery in combination with chemoradiation therapy (CRT), the overall 5-year survival has not improved more than 50%. The underlying reasons for this dismal prognosis is the intrinsic or acquired resistance to CRT. While previous studies were focused to target tumor cells, recent findings have implicated the involvement of tumor microenvironment (TME) on tumor progression and response to therapy. HNSCC TME includes cancer-associated fibroblasts (CAFs), endothelial cells, immune cells, endocrine cells, and the extracellular matrix (ECM) proteins including collagen and fibronectin. Understanding the crosstalk between TME and cancer cells is important to formulate more effective novel therapies and to overcome resistance mechanisms. Here, we summarized the current literature on recent advances on HNSCC TME with special emphasis on novel cell–cell interactions and therapies currently under development.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
Number of pages21
StatePublished - 2020

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019


  • Cancer-associated fibroblasts
  • Chemo-Radiation Therapy
  • Disease Free Survival
  • Extracellular matrix
  • Genetically Engineered Mouse Models
  • Head and Neck Squamous Cell Carcinoma
  • Immune infiltration
  • Myeloid-Derived Suppressor Cells
  • Oral Squamous Cell Carcinoma
  • Overall survival
  • Targeted Therapy
  • Tumor Microenvironment

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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