Recent advances in organoid development and applications in disease modeling

Sanchita Rauth, Saswati Karmakar, Surinder K. Batra, Moorthy P. Ponnusamy

Research output: Contribution to journalReview articlepeer-review

Abstract

An improved understanding of stem cell niches, organogenesis, and disease models has paved the way for developing a three-dimensional (3D) organoid culture system. Organoid cultures can be derived from primary tissues (single cells or tissue subunits), adult stem cells (ASCs), induced pluripotent stem cells (iPSCs), or embryonic stem cells (ESCs). As a significant technological breakthrough, 3D organoid models offer a promising approach for understanding the complexities of human diseases ranging from the mechanistic investigation of disease pathogenesis to therapy. Here, we discuss the recent applications, advantages, and limitations of organoids as in vitro models for studying metabolomics, drug development, infectious diseases, and the gut microbiome. We further discuss the use of organoids in cancer modeling using high throughput sequencing approaches.

Original languageEnglish (US)
Article number188527
JournalBiochimica et Biophysica Acta - Reviews on Cancer
Volume1875
Issue number2
DOIs
StatePublished - Apr 2021

Keywords

  • Disease modeling
  • Gut MIcrobiota
  • Metabolism
  • Organoids
  • Tumor microenvironment

ASJC Scopus subject areas

  • Oncology
  • Genetics
  • Cancer Research

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