Recent advances on the molecular mechanisms involved in pancreatic cancer progression and therapies

Murielle Mimeault, Randall E. Brand, Aaron A. Sasson, Surinder K. Batra

Research output: Contribution to journalReview article

85 Scopus citations

Abstract

This review describes the recent advances in the molecular events involved in pancreatic cancer initiation, progression, and metastasis. Additionally, the importance of deregulated cellular signaling elements as potential targets for developing novel therapeutic strategies against incurable forms of pancreatic cancer is reported. The emphasis is on the critical functions gained by numerous growth factors and their receptors, such as epidermal growth factor receptor, hedgehog signaling, and proangiogenic agents such as vascular endothelial factor and interleukin-8 for the sustained growth, survival, and metastasis of pancreatic cancer cells. The molecular mechanisms associated with antitumoral properties and the clinical benefits of gemcitabine alone or in combination with other cytotoxic agents for the treatment of pancreatic cancer are discussed.

Original languageEnglish (US)
Pages (from-to)301-316
Number of pages16
JournalPancreas
Volume31
Issue number4
DOIs
StatePublished - Nov 2005

Keywords

  • Combination therapy
  • Diagnosis
  • Epidermal growth factor epidermal growth factor receptor system
  • Gemcitabine
  • Pancreas carcinogenesis

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

Fingerprint Dive into the research topics of 'Recent advances on the molecular mechanisms involved in pancreatic cancer progression and therapies'. Together they form a unique fingerprint.

  • Cite this