Receptor-binding changes in copper-deficient rats

J. D. Geiger, P. K. Seth, L. M. Klevay, S. S. Parmar

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Male weanling Sprague-Dawley rats were fed a copper-deficient diet for 40 days. Copper-deficient rats weighed significantly (p < 0.001) less (175 ± 7 g) than copper-supple-mented rats (230 ± 6 g). Hematocrits were also significantly (p < 0.001) decreased in deficient as compared to control animals from 43 ± 0.6 to 30 ± 2.7%. The binding of3H-QNB to striatal and cerebellar membrane muscarinic receptors from control and deficient rats increased from 594 ± 25 to 704 ± 31 (p < 0.02) and from 19 ± 2 to 28 ± 3 (p < 0.01) pmol/g protein, respectively. Similarly, 3H-muscimol binding to GABA receptors (cerebellum) also increased from 39 ± 5 to 58 ± 3 (p < 0.02) pmol/g protein.3H-diazepam binding to benzodiazepine receptors in deficient versus control animal frontal cortex membranes decreased from 92 ± 8 to 75 ± 5 (p < 0.02) pmol/g protein, respectively. These results may help explain CNS manifestations of copper deficiency.

Original languageEnglish (US)
Pages (from-to)196-202
Number of pages7
JournalPharmacology
Volume28
Issue number4
DOIs
StatePublished - Jan 1 1984

    Fingerprint

Keywords

  • Benzodiazepine receptor
  • Copper deficiency
  • Receptor binding

ASJC Scopus subject areas

  • Pharmacology

Cite this

Geiger, J. D., Seth, P. K., Klevay, L. M., & Parmar, S. S. (1984). Receptor-binding changes in copper-deficient rats. Pharmacology, 28(4), 196-202. https://doi.org/10.1159/000137962