Recognition of DNA topology in reactions between plasmid DNA and cationic copolymers

T. K. Bronich, H. K. Nguyen, A. Eisenberg, A. Kabanov

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

The recognition of DNA tertiary structure is observed by the synthetic polycation. This is unprecedented for polyelectrolyte complexes of DNA. To increase stability of the complexes in aqueous dispersions, block and graft copolymers containing polycation and nonionic water-soluble polymer chains are developed. Binding of these copolymers with DNA chains results in formation of species containing hydrophobic regions from neutralized DNA and polycation. By changing composition of the complex and polycation structure, one can vary physicochemical properties and optimize biological activity of the complexes.

Original languageEnglish (US)
Title of host publicationAmerican Chemical Society, Polymer Preprints, Division of Polymer Chemistry
PublisherACS
Pages1006-1007
Number of pages2
Volume41
Edition1
StatePublished - Mar 2000
EventThe San Francisco Meeting - San Francisco, CA, USA
Duration: Mar 26 2000Mar 31 2000

Other

OtherThe San Francisco Meeting
CitySan Francisco, CA, USA
Period3/26/003/31/00

ASJC Scopus subject areas

  • Polymers and Plastics

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    Bronich, T. K., Nguyen, H. K., Eisenberg, A., & Kabanov, A. (2000). Recognition of DNA topology in reactions between plasmid DNA and cationic copolymers. In American Chemical Society, Polymer Preprints, Division of Polymer Chemistry (1 ed., Vol. 41, pp. 1006-1007). ACS.